Professor

Email: liuzhu@mail.hzau.edu.cn

Research Interest:

I am interested in protein dynamics and enzymatic mechanisms. By using an integrative strategy with multiple biophysical tools, including single-molecule fluorescence, NMR, crystallography, chemical cross-linking coupled with mass spectroscopy, and small-angle X-ray scattering, my research characterized the functional roles of protein dynamics and added insights into the mechanisms underlying enzyme catalysis.

Lecture：Biochemistry

Graduate students who are interested in biophysics are welcomed. 2-3 Posdoctor positions are available.

Education: 

2009 - 2014：

Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Ph.D.

2005 - 2009：

College of Chemistry and Molecular Sciences, Wuhan University, B.S.

Professional Experiences:

2018 - present: Professor

College of Life Science and Technology, Huazhong Agricultural University, National Key Laboratory of Crop Genetic Improvement, Wuhan, China.

2017 - 2018：Assistant Professor

Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences , Wuhan, China.

2014 - 2017：Postdoctoral fellow

School of Medicine, Zhejiang University, Hangzhou, China.

Selected Publications:

1.        Zhou C^#, Yan L^#, Zhang WH, Liu Z^*. Structural basis of tubulin detyrosination by VASH2/SVBP heterodimer. Nature Communications. 2019, 10(1):3212.

2.        Liu Z^#, Dong X^#, Yi HW, Yang J, Gong Z, Wang Y, Liu K, Zhang WP^*, Tang C^*. Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Cell Discovery. 2019, 5:9.

3.        Liu Z, Gong Z, Cao Y, Ding YH, Dong MQ, Lu YB, Zhang WP, Tang C^*. Characterizing Protein Dynamics with Integrative Use of Bulk and Single-Molecule Techniques. Biochemistry. 2018, 57:305-313.

4.        Dong X^#, Gong Z^#, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z^*, Zhang WP^*, Tang C^*. Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci, USA. 2017, 114:6770-6775.

5.        Liu Z, Gong Z, Dong X and Tang C^*. Transient protein-protein interactions visualized by solution NMR. BBA Proteins and Proteomics. 2016, 1864:115-122.

6.        Liu Z, Gong Z, Jiang WX, Yang J, Zhu WK, Guo DC, Zhang WP, Liu ML^* and Tang C^*. Lys63-linked ubiquitin chain adopts multiple conformational states for specific target recognition. 2015, Elife,4:e05767.

7.        Liu Z, Gong Z, Guo DC, Zhang WP^* and Tang C^*. Subtle dynamics of holo glutamine binding protein revealed with a rigid paramagnetic probe. Biochemistry. 2014, 53, 1403-1409.

8.        Liu Z, Zhang WP, Xing Q, Ren XF, Liu ML^* and Tang C^*. Noncovalent dimerization of ubiquitin. 2012, Angew Chem Int Ed, 51, 469-472. (hot paper).