Professor

Email: hejingjj@mail.hzau.edu.cn

Research Interest:

Biosynthesis, regulation and resistance mechanism of natural products from microorganisms

Education:   

2005.01-2001.11 Doctor of Science (Microbiology), Hans-Knoell-Institute for Natural Products Research,

                            The University of Jena (Friedrich-Schiller-Universität Jena), Jena, Germany

1999.09-2001.06 Master of Science (Molecular Biology and Biochemistry), College of Life Science and Technology,

                            Huazhong Agricultural University, Wuhan, China

1995.09-1999.06 Bachelor of Science (Biotechnology), College of Life Science and Technology,

                            Huazhong Agricultural University, Wuhan, China

Professional Experiences:

2008.09-present   Professor, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China

2008.08-2007.09 Postdoctor, Department of Chemistry, The University of Chicago, Chicago, USA

2007.03-2005.04 Postdoctor, Kekulé Institute of Organic Chemistry and Biochemistry,

                                               The University of Bonn (Rheinische Friedrich-Wilhelms-Universität Bonn), Bonn, Germany

Selected Publications:

1.        Xiaorong Chen, Yuedi Sun, Shan Wang, Kun Ying, Le Xiao, Kai Liu, Xiuli Zuo, Jing He*. Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks. Nucleic Acids Res. 2020, 48(2):709-718.

2.        Qin Liu, Qin Lin, Xinying Li, Muhammad Ali, Jing He*. Construction and application of a "superplasmid" for enhanced production of antibiotics. Appl Microbiol Biotechnol. 2020, 104(4):1647-1660.

3.        Mengyi Zhu, Lijuan Wang, Jing He*. Chemical diversification based on substrate promiscuity of a standalone adenylation domain in a reconstituted NRPS system. ACS Chem Biol. 2019, 14(2):256-265. 

4.        Mengyi Zhu^#, Lijuan Wang^#, Qingbo Zhang, Muhammad Ali, Siqi Zhu, Peiqing Yu, Xiaofei Gu, Haibo Zhang, Yiguang Zhu, Jing He*. Tandem hydration of diisonitriles triggered by isonitrile hydratase in Streptomyces thioluteus. Org Lett. 2018, 20(12):3562-3565.

5.        Lijuan Wang^#, Mengyi Zhu^#, Qingbo Zhang, Xu Zhang, Panlei Yang, Zihui Liu, Yun Deng, Yiguang Zhu, Xueshi Huang, Li Han, Shengqing Li, Jing He*. Diisonitrile natural product SF2768 functions as a chalkophore that mediates copper acquisition in Streptomyces thioluteus. ACS Chem Biol. 2017, 12(12):3067-3075.

6.        Shan Wang, Kai Liu, Le Xiao, LiYuan Yang, Hong Li, FeiXue Zhang, Lei Lei, ShengQing Li, Xu Feng, AiYing Li, Jing He*. Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage. Nucleic Acids Res. 2016, 44(1):187-197.

7.        Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang, Jing He*. Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway. Biochem Biophys Res Commun. 2016, 473(1):329-335.

8.        Shan Wang, Ruifang Zhao, Kai Liu, Mengyi Zhu, Aiying Li, Jing He*. Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi. FEMS Microbiol Lett. 2012, 337(2):147-154.

9.        Sheng Huang, Yudong Zhao,Zhiwei Qin, Xiaoling Wang, Mayca Onega, Li Chen, Jing He*, Yi Yu*, Hai Deng*. Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus. Process Biochemistry. 2011, 46(3):811-816.

10.    Jing He and Christian Hertweck. Functional analysis of the aureothin iterative type I polyketide synthase. ChembioChem. 2005, 6(5):908-912.

11.    Jing He, Markus Müller, Christian Hertweck*. Formation of the aureothin tetrahydrofuran ring by a bifunctional cytochrome P450 monooxygenase. J. Am. Chem. Soc. 2004, 126(51):16742-16743.  

12.    Jing He, Christian Hertweck*. Biosynthetic origin of the rare nitro aryl moiety of the polyketide antibiotic aureothin: discovery of an unprecedented N-oxygenase. J. Am. Chem. Soc. 2004, 126(12):3694-3695.

13.    Jing He and Christian Hertweck*. Iteration as programmed event during polyketide assembly; molecular analysis of the aureothin biosynthesis gene cluster. Chem. Biol. 2003, 10(12):1225-1232.